ABSTRACT
To determine the changes in the serum insulin levels in alloxan induced diabetic albino rats in comparison with oral hypoglycemic drugs. An experimental study. This study was conducted at Al Tibri Medical College Karachi during December 2012 to December 2013. The present study was conducted on 60 Albino rats which were group from A to F consisting of 10 rats in each group. These groups were further divided into two sub groups which were treated with low dose and high dose of the cinnamon and oral hypoglycemic drugs. The results showed that there is significant reduction in serum insulin level in the alloxan treated group animals which was improved in group C animals treated with low dose of cinnamon extract in alloxan induced diabetic rats. Also animals in group D and group E treated with tolbutamide and acarbose respectively showed higher increase in serum insulin level as compared with cinnamon extract treated groups, however when cinnamon extract was used in combination with tolbutamide or acarbose it showed synergetic effects. Tolbutamide and Acarbose treated groups showed better anti diabetic effect by increasing the serum insulin level in comparison with cinnamon extract treated groups when used individually. This effect was enhanced when cinnamon extract was used in combination with either tolbutamide or acarbose
ABSTRACT
To evaluate the role of monocyte count in patients presenting for coronary artery heart disease and to assess its significance as a risk factor. Cross sectional study. This study was carried on the patients taken from Coronary Care Unit [CCU] Department of Isra University Hospital, Dewan-e-Mushtaque CCU and from Red Crescent Hospital CCU from May 2011 to October 2011. In this study 140 individuals were enrolled to observe the monocyte count in patients with coronary artery disease. In control group 42, Stable Coronary Artery Disease [CAD] 34 and Acute Myocardial Infarction [AMI] 64 individuals were taken. Three ml of blood was collected in EDTA bottles for differential leukocyte count [DLC] from each patient presenting with chest pain in coronary care unit. The total leukocyte count [TLC] and other parameters were determined by different automatic analyzers in the clinical laboratory. In all three groups male predominance with 70/o, 64% and 64% in Stable CAD, control, and AMI group was seen respectively. In stable CAD group highest percentage [53%] of patients were seen in 56 to 65 years age followed by 50% of patients of 35-45 years and 42% of patients of 46-55 years in control and AMI group respectively. Both in stable CAD and AMI groups; monocyte count was highly significant in diabetic patients however in individuals with higher BMI; monocyte count was significantly increased in AMI group than stable CAD and control groups. It is concluded from the present study that monocyte count has significant relationship between clinical stages of CAD and diabetic patients. However individuals with higher BMI showed significant high levels of monocyte count in AMI group only
ABSTRACT
The aim of this study was to evaluate the patterns of Beta Thalassaemia in children suffered with microcytic hypochromic anemia in the different hospital of Hyderabad region. Cross-sectional study. This is an experimental based research study that was conducted at Isra University Hospital, Hyderabad and Liaquat University of Medical and Health Sciences Hospital Jamshoro Hyderabad from June 2011 to February 2012. Hundred [100] children from either gender attending outpatient department of Isra University Hospital and Liaquat University Hospital Hyderabad were selected for this study. Whole blood sample [10ml] was collected from each children. Peripheral smears were made and found that all children have suffered with findings of microcytic hypchromic anemia. Children with other than microcytic hypochromic anemia were excluded from this study. All parents of children were interviewed regarding family history and marriages with cousin and other findings or histories were also recorded on a well designed performa. Whole blood samples were analyzed for the evaluation of the patterns of Beta Thalassaemia in 100 children who were affected with microcytic hypochromic anemia. Out of 100 children, 08 of them were diagnosed as having beta thalassaemia minor, one as Beta Thalassaemia major and the remaining 91 were non thalassaemics. Among 08 Beta Thalassaemic minor children, 05 were females and 03 were males and only one male child was suffered with beta thalassaemia major. It is concluded that the prevalence level of beta thalassaemia is higher in Hyderabad, which is an alarming. Many factors such as poor facilities for diagnosis, lack of awareness among clinicians, consultants and pathologists and high cost of molecular diagnosis play a contributory role in the propagation of the beta thalassaemia in the Pakistani population. These factors become a serious hindrance for the prevention of thalassaemic program in Pakistan
ABSTRACT
Objectives: To find out the simple, economical and diagnostic test for detecting Acute Myocardial Infraction [AMI] at distant areas
Study Design: Cross sectional study
PLACE AND DURATION: Six months
Methodology: 03 ml of blood sample was collected from 140 patients presenting to the Emergency /Coronary Care Units of hospitals viz Isra University Hyderabad, Red Crescent Hyderabad and Civil Hospital Hyderabad. The slides were prepared and white blood cells were counted microscopically at Post Graduate laboratory of Isra University Hyderabad
Results: In present study Neutrophil/Lymphocyte [N/L] ratio was observed and compared in both subjects [cardiac and non-cardiac]
The N/L ratio was found to be normal in non-cardiac patients but was significantly raised in patients with myocardial infarction
Especially in Acute Myocardial Infarction with ST segment elevation [AMI-STE] in comparison to Acute Myocardial Infarction with non STsegment elevation [AMI-NSTE] was also observed [p< 0.001]
Conclusion: The N/L ratio was significantly raised in patients with AMI suggesting an additional diagnostic parameter for AMI at primary health care units